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EPFL, the Swiss Federal Institute of Technology in Lausanne, is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs more than 6,500 people supporting the three main missions of the institutions: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of more than 17,000 people, including over 12,500 students and 4,000 researchers from more than 120 different countries.

Postdoctal Research Position: Tumor Cell Biology-T Cell Acute Lymphoblastic Leukemia (T-ALL)

Mission

The UPRAD laboratory (Professor Freddy Radtke), Science de la Vie (SV) Faculty, at the Swiss Federal Institute of Technology, offers a postdoctoral research position (100%) to decipher transcription factor-mediated chromatin remodeling and epigenetic regulatory functions in oncogenic Notch1-driven T-ALL utilizing animal models of cancer and hematopoiesis.


The UPRAD laboratory has a specific focus on basic and translational cancer research. Using state-of-the art technologies, including omics analysis (transcriptomic, epigenetic, single cell analysis, proteomics), genetical engineered mouse models, organoids, patient-derived xenografts as well as primary human clinical samples, we aim to unravel molecular and mechanistic events driving the initiation and progression of blood borne cancers and solid tumors.


You will extend a previous research endeavor (https://doi.org/10.1182/blood.2021012077) to unravel the single or combined role of two crucial transcription factors and/or chromatin remodelers in established T-ALL disease settings. A major interest is to evaluate how specific transcription factors are involved in shaping the pre-leukemic state and subsequently maintenance of Notch1-driven T-ALL by assessing the chromatin structure of transformed leukemic cells. Using epigenetic analysis tools downstream after extracting stage-specific leukemic cells, you will be able to perform functional studies including but not limited to proliferation and cell cycle analysis, apoptosis, RNA- and ATAC-seq.

 

  • Koch, U. and Radtke, F., (2011). Notch in T-ALL: New players in a complex disease. Trends Immunol 23(9): 434-42. DOI:10.1016/j.it.2011.06.005
  • Antoszewski, M. et al., (2021). Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL. Blood 139(16): 2483-98. DOI:10.1182/blood.2021012077

Main duties and responsibilities

Driving force in conducting the research, develop the experimental designs and work in collaboration with the hematopoiesis team in the lab and bioinformaticians.

 

  • Responsible for experimental design, conducting the experiment, data acquisition and critical evaluation
  • Reporting of research results in lab meetings, seminars, conferences and writing scientific articles

Profile

The ideal candidate should have:

 

  • PhD degree in cell biology with a solid background in cancer biology, hematopoiesis and/or genetics required
  • Experience in designing and handling experimental animal models (mouse) of blood borne cancers 
  • Experience in multiparameter flow cytometry
  • Experience in tissue culture, cloning techniques and epigenetic techniques
  • Experience in Scientific Computing Software (Python, Linux) will be a plus
  • LTK1 module or equivalent required
  • Working knowledge of laboratory information system (LIMS), electronic laboratory notebook (ELN) and statistical analysis are beneficial
  • Language skills - good knowledge of English (verbal and writing) a prerequisite
  • Good communication and organizational skills
  • Capacity to collaborate to achieve common objectives
  • Good management and interpersonal skills

We offer

An opportunity to work in cutting-edge projects in a world-renowned scientific community with esteemed scientists, engineers and clinicians. You will work in a dynamic, multidisciplinary, multicultural and collaborative laboratory environment.

EPFL is an international and world-class engineering institution that hosts state-of-the-art experimental and computational facilities, as well as a rich and vibrant scientific and entrepreneurial community.

EPFL is an equal-opportunity employer. We offer competitive salary and benefits, defined by EPFL scales and regulations.

Informations

Contract Start Date : as soon as possible  

Activity Rate : 100 % 

Contract Type: CDD

Duration: 1 year, renewable 

Only application through our plateform will be taken into account, at this stage your application shall include:

  • a brief motivation letter (pdf, up to 2 pages)
  • a second pdf that includes -> CV, list of publications, contact details of three referees

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