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EPFL, the Swiss Federal Institute of Technology in Lausanne, is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs more than 6,500 people supporting the three main missions of the institutions: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of more than 18,500 people, including over 14,000 students and 4,000 researchers from more than 120 different countries.

Senior Clinical Trial Manager

Short Description

The Laboratory for Intelligent Global Health and Humanitarian Technologies (LiGHT) at EPFL is seeking an experienced Senior Clinical Trial Manager (CTM) to lead and oversee multi-country clinical trials evaluating AI-enabled clinical decision support tools in low- and middle-income countries (LMICs), with a focus on Sub-Saharan Africa and India.

This is a unique opportunity to contribute to mission-driven, high-impact research advancing safe, equitable, and high-quality healthcare in underserved settings. The ideal candidate combines operational excellence with empathy, analytical thinking, and the ability to work effectively in diverse, international teams.

 

Mission

The Laboratory for Intelligent Global Health and Humanitarian Response Technologies (LiGHT)  https://www.light-laboratory.org/ is an impact-driven research group creating novel AI tools specifically adapted to limited-resource and volatile global health settings and bringing them to scaled, locally owned implementation.

It is based at the Swiss Institute of Technology (EPFL) – In the top 10 computer science institutions globally, EPFL is a deeply international hub for technical excellence in AI.

Our mission is to develop safe, scalable, and context-aware digital health tools. We work with international NGOs such as WHO, MSF, ICRC, and national ministries of health to design, create, validate and deploy trustworthy AI in real-world healthcare systems—especially in settings where clinical resources are limited and stakes are high.

Main duties and responsibilities

Clinical Trial Operations

  • Lead end-to-end implementation of global clinical trials from feasibility through close-out
  • Oversee site identification, initiation, monitoring, and close-out, ensuring compliance with ICH-GCP and local regulations
  • Coordinate regulatory and ethics submissions, approvals, and communications in LMIC contexts
  • Act as the primary operational contact for CROs, vendors, and research sites
  • Monitor study progress, timelines, and budgets, identifying and resolving challenges proactively
  • Lead investigator meetings, site trainings, and monitoring visits, ensuring effective collaboration and adherence to protocols

Quality & Compliance

  • Ensure all trial activities meet ICH-GCP, local regulatory, and ethical standards
  • Conduct and oversee on-site, remote, and centralized monitoring to maintain data integrity and participant safety
  • Identify and mitigate risks and operational issues, maintaining comprehensive documentation
  • Support audit and inspection readiness, contributing to continuous improvement initiatives
  • (Preferred) Contribute to or support the maintenance and documentation of the Quality Management System (QMS) to strengthen quality oversight

Team Leadership & Capacity Strengthening

  • Supervise and mentor Clinical Operations team members and CRAs, offering guidance and support
  • Strengthen local research capacity through training and ongoing knowledge exchange
  • Collaborate with data management, biostatistics, and regulatory affairs teams to ensure cohesive project delivery

Partnerships & Cross-Cultural Collaboration

  • Build and maintain strong partnerships with clinical sites, investigators, and local research institutions
  • Work effectively in multicultural, international, and multidisciplinary environments
  • Demonstrate cultural sensitivity, inclusion, and adaptability in all interactions
  • Support the ethical and context-appropriate integration of AI-enabled tools into real-world healthcare settings

Documentation & Reporting

  • Maintain accurate and complete Trial Master File (eTMF) and operational records
  • Prepare study progress reports, monitoring summaries, and final reports
  • Contribute to scientific publications, presentations, and regulatory submissions as required

Profile

  • Advanced degree in life sciences, medicine, public health, or a related field
  • 4+ years of hands-on clinical trial management experience, ideally in multi-country interventional studies within LMICs
  • Proven expertise in clinical monitoring, data verification, and quality assurance
  • Comprehensive understanding of ICH-GCP and international regulatory requirements
  • Experience with EDC systems, (e)TMF, and Quality Management Systems (QMS) preferred
  • Familiarity with AI, digital health, or medical device studies is an advantage
  • Demonstrated ability to manage cross-functional teams and collaborate effectively across geographies and cultures
  • Fluency in English required; French proficiency strongly preferred (for collaboration in West Africa)
  • Willingness to travel internationally up to 30% (Africa and India)
  • Proactivity and independence in managing complex, multi-site projects
  • Strong analytical and problem-solving skills, with attention to detail and process improvement
  • Excellent organizational and time management abilities to balance multiple priorities effectively
  • Team integration and collaboration, fostering a supportive, solution-oriented work environment
  • Empathy and emotional intelligence, particularly when working with diverse cultural and professional backgrounds
  • Cultural sensitivity and adaptability in international and resource-limited settings
  • Solution-oriented mindset and resilience under pressure
  • Integrity, accountability, and commitment to ethical and high-quality research

We offer

  • Mission-driven work at the intersection of technology, health, and global equity
  • Opportunity to shape open-source platforms used by WHO, ICRC, and other partners
  • A creative, ambitious, and collaborative team across continents
  • Excellent working conditions

 

What We Value

At LiGHT, we work with care and rigor. We value curiosity, collaboration, principled innovation, and design that serves. Our tools are used in the real world—so they must be beautiful, robust, and intuitive under pressure. You’ll be joining a team that thrives on meaningful challenge, creativity, and a shared mission.

 

Informations

Contract Start Date : 01/01/2026 

Activity Rate : 100.00 

Contract Type: CDD

Duration: 1 year, renewable 

Reference: 1890 










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